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Επιστημονικά άρθρα – βιβλία

1. Malliaras K, et al. Intracoronary cardiosphere-derived cells after myocardial infarction: evidence for therapeutic regeneration in the final 1-year results of the CADUCEUS trial. J Am Coll Cardiol 2014 21;63(2):110-22.
2. Malliaras K, at al. Validation of contrast-enhanced MRI to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction. Circulation 2013;128(25):2764-75.
3. Malliaras K, et al. Safety and Efficacy of Allogeneic Cell Therapy in Infarcted Rats Transplanted with Mismatched Cardiosphere-Derived Cells. Circulation 2012;125:100-12.
4. Malliaras K, Marbán E. Cardiac regeneration validated. Nature Biotechnology. 2015;33(6):587.
5. Malliaras K, et al. Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. EMBO Mol Med. 2014;6(6):760-77.
6. Malliaras K, et al. Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med 2013 2013;5:191-209.
7. Malliaras K, Marbán E. Cardiac cell therapy: where we’ve been, where we are, and where we should be headed. Br Med Bull. 2011;98:161-85.
8. Malliaras K, et al. Innate heart regeneration: endogenous cellular sources and exogenous therapeutic amplification. Expert Opin Biol Ther. 2016;16(11):1341-1352.
9. Malliaras K, Marbán E. Moving beyond surrogate endpoints in cell therapy trials for heart disease. Stem Cells Transl Med 2014;3(1):2-6.
10. Malliaras K, et al. The stuttering progress of cell therapy for heart disease. Clin Pharmacol Ther. 2011;90:532-41.
11. Malliaras K, Terrovitis J. Cardiomyocyte proliferation vs progenitor cells in myocardial regeneration: The debate continues. Glob Cardiol Sci Pract. 2013;2013(3):303-315./td>
12. Malliaras K, et al. Effects of intra-aortic balloon pump counterpulsation on left ventricular mechanoenergetics in a porcine model of acute ischemic heart failure. J Cardiovasc Transl Res. 2014;7(9):810-20.
13. Malliaras K, et al. Lack of macroscopically evident cardiac regeneration or spontaneous functional recovery in infarcted neonatal pigs. Hellenic J Cardiol. 2020;61(3):219-221.
14. Malliaras K, et al. Reverse cardiac remodeling enabled by mechanical unloading of the left ventricle. J Cardiovasc Transl Res. 2009;2(1):114-25.
15. Makkar RR, Smith RR, Cheng K, Malliaras K, et al. Heart regeneration after myocardial infarction in patients treated with intracoronary cardiosphere-derived cells: results of a first-in-human prospective, randomised trial. Lancet 2012;379:895-904.
16. Marbán E, Malliaras K. Bone marrow-derived cell therapy after myocardial infarction-reply. JAMA 2012;308:2405-6.
17. Marbán E, Malliaras K. Mixed Results for Bone Marrow-Derived Cell Therapy for Ischemic Heart Disease. JAMA. 2012;308:2405-6
18. Makkar RR, Kereiakes DJ, Aguirre F, Kowalchuk G, Chakravarty T, Malliaras K, et al. Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial. Eur Heart J. 2020;41(36):3451-3458.
19. Sousonis V, Sfakianaki T, Ntalianis A, Nanas I, Kontogiannis C, Aravantinos D, Kapelios C, Katsaros L, Nana M, Sampaziotis D, Sanoudou D, Papalois A, Malliaras K. Intracoronary Administration of Allogeneic Cardiosphere-Derived Cells Immediately Prior to Reperfusion in Pigs With Acute Myocardial Infarction Reduces Infarct Size and Attenuates Adverse Cardiac Remodeling. J Cardiovasc Pharmacol Ther. 2021;26(1):88-99.
20. Kapelios CJ, Bonou Μ, Malliaras K, et al. Association of loop diuretics use and dose with outcomes in outpatients with heart failure: a systematic review and meta-analysis of observational studies involving 96,959 patients. Heart Fail Rev. 2022;27(1):147-161.
21. Sanidas E, Malliaras K, et al. Antihypertensive therapy and sudden cardiac death, should we expect the unexpected? J Hum Hypertens. 2020;34(5):339-345.
22. Chakravarty T, Henry TD, Kittleson M, Lima J, Siegel RJ, Slipczuk L, Pogoda JM, Smith RR, Malliaras K, et al. Allogeneic cardiosphere-derived cells for the treatment of heart failure with reduced ejection fraction: the Dilated cardiomYopathy iNtervention with Allogeneic MyocardIally-regenerative Cells (DYNAMIC) trial. EuroIntervention. 2020 Jul 17;16(4):e293-e300
23. Masoura C, Malliaras K, et al. Think of fibromuscular dysplasia whenever spontaneous coronary artery dissection presents. Hellenic J Cardiol. 2020;61(3):210-213.
24. Taylor M, Jefferies J, Byrne B, Lima J, Ambale-Venkatesh B, Ostovaneh MR, Makkar R, Goldstein B, Smith RR, Fudge J, Malliaras K, et al. Cardiac and skeletal muscle effects in the randomized HOPE-Duchenne trial. Neurology. 2019;92(8):e866-e878.
25. Kaldara E, Malliaras K, et al. A Novel Simple Diagnostic Algorithm for Rapid and Accurate Detection of Anemia Etiology in Patients With Advanced Heart Failure. J Card Fail. 2018;24(11):806-807.
26. Nana-Leventaki E, Nana M, Poulianitis N, Sampaziotis D, Perrea D, Sanoudou D, Rontogianni D, Malliaras K (corresponding author). Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis. J Cardiovasc Pharmacol Ther. 2019;24(1):70-77.
27. Kontogiannis C, Aravantinos D, Nanas I, Kapelios CJ, Marinakis S, Vakrou S, Sarchosi S, Perrea DN, Mason JW, Nanas JN, Malliaras K. Salutary Effects of the PULVAD, a Novel Implantable Counterpulsation Assist Device, on Cardiac Mechanoenergetics. ASAIO J. 2018 Jun 5.
28. Sventzouri S, Nanas I, Vakrou S, Kapelios C, Sousonis V, Sfakianaki T, Papalois A, Manolis AS, Nanas JN, Malliaras K. Pharmacologic inhibition of the mitochondrial Na+/Ca2+ exchanger protects against ventricular arrhythmias in a porcine model of ischemia-reperfusion. Hellenic J Cardiol. 2018;59(4):217-222.
29. Kapelios CJ, Malliaras K, et al. Loop diuretics for chronic heart failure: a foe in disguise of a friend? Eur Heart J Cardiovasc Pharmacother. 2018;4(1):54-63.
30. Bonios MJ, Anastasiou-Nana M, Perrea DN, Malliaras K. A combined cellular and surgical ventricular reconstruction therapeutic approach produces attenuation of remodeling in infarcted rats. Hellenic J Cardiol. 2017;58(2):135-142.
31. Repasos E, Kaldara E, Pantsios C, Kapelios C, Nana E, Vernadakis S, Melexopoulou C, Malliaras K, et al. Arteriovenous renal replacement therapy in end-stage left-sided heart failure patients has a detrimental effect on patients with impaired right ventricular function. Hellenic J Cardiol. 2017;58(4):276-280.
32. Tsamatsoulis M, Kapelios CJ, Katsaros L, Vakrou S, Sousonis V, Sventzouri S, Michelinakis N, Perrea DN, Anastasiou-Nana M, Malliaras K. Cardioprotective effects of intracoronary administration of 4-chlorodiazepam in small and large animal models of ischemia-reperfusion. Int J Cardiol. 2016;224:90-95.
33. Zagorianou A, Marougkas M, Drakos SG, Diakos N, Konstantopoulos P, Perrea DN, Anastasiou-Nana M, Malliaras K. The effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy. Springerplus. 2016;5(1):1568.
34. Kapelios CJ, Malliaras K, Nanas JN. Dosing of loop diuretics in chronic heart failure: it's time for evidence. Eur J Heart Fail. 2016;18(10):1298.
35. Koudoumas D, Malliaras K, et al. Long-Term Intra-Aortic Balloon Pump Support as Bridge to Left Ventricular Assist Device Implantation. J Card Surg. 2016;31(7):467-71.
36. Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ; ACCRUE Investigators. Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies. Circ Res. 2016;118(8):1254-63.
37. Kontogiannis CD, Malliaras K, et al. Continuous internal counterpulsation as a bridge to recovery in acute and chronic heart failure. World J Transplant. 2016;6(1):115-24.
38. Kanazawa H, Tseliou E, Dawkins JF, De Couto G, Gallet R, Malliaras K, et al. Durable Benefits of Cellular Postconditioning: Long-Term Effects of Allogeneic Cardiosphere-Derived Cells Infused After Reperfusion in Pigs with Acute Myocardial Infarction. J Am Heart Assoc. 2016;5(2). pii: e002796.
39. Kapelios CJ, Nanas JN, Malliaras K. Allogeneic cardiosphere-derived cells for myocardial regeneration: current progress and recent results. Future Cardiol. 2016;12(1):87-100.
40. Pantsios C, Kapelios C, Vakrou S, Diakos N, Pozios I, Kontogiannis C, Nanas J, Malliaras K. Effect of Elevated Reperfusion Pressure on "No Reflow" Area and Infarct Size in a Porcine Model of Ischemia-Reperfusion. J Cardiovasc Pharmacol Ther. 2016;21(4):405-11.
41. Tzanis G, Manetos C, Dimopoulos S, Vasileiadis I, Malliaras K, et al. Attenuated Microcirculatory Response to Maximal Exercise in Patients With Chronic Heart Failure. J Cardiopulm Rehabil Prev. 2016;36(1):33-7.
42. 41. Tzanis G, Manetos C, Dimopoulos S, Vasileiadis I, Malliaras K, et al. Attenuated Microcirculatory Response to Maximal Exercise in Patients With Chronic Heart Failure. J Cardiopulm Rehabil Prev. 2016;36(1):33-7.
43. Ntalianis A, Kapelios CJ, Kanakakis J, Repasos E, Pantsios C, Nana E, Kontogiannis C, Malliaras K, et al. Prolonged intra-aortic balloon pump support in biventricular heart failure induces right ventricular reverse remodeling. Int J Cardiol. 2015;192:3-8.
44. Gyöngyösi M, Wojakowski W, Lemarchand P, Lunde K, Tendera M, Bartunek J, Marban E, Assmus B, Henry TD, Traverse JH, Moyé LA, Sürder D, Corti R, Huikuri H, Miettinen J, Wöhrle J, Obradovic S, Roncalli J, Malliaras K, et al. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res. 2015;116(8):1346-60.
45. Repasos E, Kaldara E, Ntalianis A, Pantsios C, Kapelios C, Nana E, Grapsa E, Malliaras K, Nanas JN. Intermittent renal replacement therapy for end stage drug refractory heart failure. Int J Cardiol. 2015;183:24-6.
46. Kanazawa H, Tseliou E, Malliaras K, et al. Cellular postconditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction. Circ Heart Fail. 2015;8(2):322-32.
47. Diakos NA, Pozios I, Katsaros L, Vakrou S, Sventzouri S, Michelinakis N, Tseliou E, Bonios M, Malliaras K, et al. Afterload-induced left ventricular diastolic dysfunction during myocardial ischaemia and reperfusion. Exp Physiol. 2015;100(3):288-301.
48. Yee K*, Malliaras K, et al. Allogeneic cardiospheres delivered via percutaneous transendocardial injection increase viable myocardium, decrease scar size, and attenuate cardiac dilatation in porcine ischemic cardiomyopathy. PLoS One. 2014;9(12):e113805.
49. Kapelios CJ, Kaldara E, Ntalianis A, Nana E, Pantsios C, Repasos E, Margari Z, Sousonis V, Malliaras K, Nanas JN. Lowering furosemide dose in stable chronic heart failure patients with reduced ejection fraction is not accompanied by decompensation: a randomized study. Int J Cardiol. 2014;177(2):690-2.
50. Aminzadeh MA, Tseliou E, Sun B, Cheng K, Malliaras K, et al. Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy. Eur Heart J. 2015;36(12):751-62.
51. Xie Y, Ibrahim A, Cheng K, Wu Z, Liang W, Malliaras K, et al. Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells. Stem Cells. 2014;32(9):2397-406.
52. Cheng K, Malliaras K, et al. Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair. JACC Heart Fail 2014;2(1):49-61.
53. Szczepaniak EW,Malliaras K, et al. Measurement of pancreatic volume by abdominal MRI: a validation study. PLoS One. 2013;8:e55991.
54. Tseliou E, Pollan S, Malliaras K,et al. Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling post-myocardial infarction in immunologically-mismatched rat strains. J Am Coll Cardiol. 2013;61:1108-19.
55. Cheng K, Shen D, Xie Y, Cingolani E, Malliaras K, Marbán E. Mechanism of Extravasation of Infused Regenerative Cells From Microvessels into Tissue Parenchyma. Stem Cells. 2012;30:2835-42.
56. Pierrakos CN, Tsolakis EJ, Pozios IA, Diakos N, Charitos E, Malliaras K, et al. Effects of l-NAME on coronary blood flow, infarct size and the extent of the no-reflow phenomenon. Int J Cardiol. 2013;167:3000-5.
57. Cheng K, Malliaras K, Let al. Magnetic enhancement of cell retention, engraftment and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion. Cell Transplantation 2012;21:1121-35.
58. Li T-S, Cheng K, Malliaras K, et al. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol. 2012;59:942-53.
59. Cheng K, Malliaras K, et al. Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction. J Am Coll Cardiol. 2012;59:256-64.
60. Drakos SG, Terrovitis JV, Nanas JN, Charitos EI, Ntalianis AS, Malliaras K, et al. Reverse electrophysiologic remodeling after cardiac mechanical unloading for end-stage nonischemic cardiomyopathy. Ann Thorac Surg. 2011;91:764-9.
61. Lee ST, White AJ, Matsushita S, Malliaras K, et al. Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol. 2011;57:455-65.
62. Stavrakis S, Terrovitis J, Tsolakis E, Drakos S, Dalianis A, Bonios M, Koudoumas D, Malliaras K, Nanas J. Relationship between retrograde coronary blood flow and the extent of no-reflow and infarct size in a porcine ischemia-reperfusion model. J Cardiovasc Transl Res. 2011;4:99-105.
63. Li TS, Cheng K, Lee ST, Matsushita S, Davis D, Malliaras K, et al. Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair Stem Cells 2010;28:2088-98.
64. Zhang Y, Li TS, Lee ST, Wawrowsky KA, Cheng K, Galang G, Malliaras K, et al. Dedifferentiation and Proliferation of Mammalian Cardiomyocytes PLoS One 2010;5:e12559.
65. Marbán E, Malliaras K. Boot camp for mesenchymal stem cells. J Am Coll Cardiol. 2010;56:735-7.
66. Li TS, Cheng K, Malliaras K, et al. Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc Res. 2010;89:157-65.
67. Cheng K, Li TS, Malliaras K, Davis DR, Zhang Y, Marbán E. Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res. 2010;106:1570-81.
68. Drakos SG, Athanasoulis T, Malliaras K, et al. Myocardial sympathetic innervation and long-term left ventricular mechanical unloading. JACC Cardiovasc Imaging. 2010;3:64-70.
69. Davis DR, Zhang Y, Smith RR, Cheng K, Terrovitis J, Malliaras K, et al. Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One. 2009;4(9):e7195.
70. Gerovasili V, Drakos S, Kravari M, Malliaras K, et al. Physical exercise improves the peripheral microcirculation of patients with chronic heart failure. J Cardiopulm Rehabil Prev. 2009;29(6):385-91.
71. Drakos SG, Anastasiou-Nana MI, Malliaras K, Nanas JN. Anemia in chronic heart failure. Congest Heart Fail. 2009;15(2):87-92.
72. Tsagalou EP, Kanakakis J, Anastasiou-Nana MI, Drakos SG, Ntalianis AS, Malliaras K, et al. Hemodynamic effects of levosimendan in acute myocardial infarction complicated by cardiogenic shock and high systemic vascular resistance. Acute Card Care. 2009;11(2):99-106.
1 Malliaras K, Marbán E. Cell Therapy for heart failure. “Heart Failure: Principles and Clinical Management”, McGraw Hill, 2013
2 Kanazawa H, Malliaras K, Kreke M, Marbán E. Cardiac cell therapy for ischemic heart disease. “Cardiac Regeneration using ES and iPS Cells”, Science Publishers, 2013.
3 Sousonis V, Malliaras K, Terrovitis J, Nanas J. Cell therapy in cardiac diseases. “Introduction to translational cardiovascular research”, Springer, 2014.
4 Malliaras K. Endogenous regeneration of the mammalian heart. “Myocardial Preservation”, Springer, 2019.
5 Malliaras K, Cokkinos DV. Cell therapy for heart disease ready for prime time or lost in translation? “Myocardial Preservation”, Springer, 2019.
6 Vakrou S, Malliaras K. Gene therapy in cardiac disease. “Myocardial Preservation”, Springer, 2019.

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